Formulation and Evaluation of Fast Dissolving Tablet of Pantoprazole Using Natural Sweetener

Abstract

Fast dissolving tablets represent a significant advancement in pharmaceutical technology, particularly benefiting patients with swallowing difficulties. Their rapid dissolution, ease of administration, and improved bioavailability make them a popular choice in many therapeutic areas, offering an alternative to traditional tablets and capsules. The current study developed Pantoprazole fast-dissolving tablets with better medication release. Superdisintegrants like Crosscarmellose sodium and sodium starch glycolate were used to make fast-dissolving tablets. Magnesium Stearate lubricates, mannitol dilutes. The direct-compression tablets passed all pharmacopoeia testing. This formulation uses stevia (Stevia rebidiana) leaf powder as a natural sweetener. The current research shows that natural sweetener may disguise Pantoprazole's harsh taste. Formulations F1, F5, and F9 discharged 84.59, 82.39, and 80.46% of medication after 10 minutes. F1, made with Sodium Starch Glycolate (8%) and pantoprazole, released the most medication after 10 minutes. F1 performs better than other formulas.