Development and Optimization of Carvedilol Microparticles
Keywords:
Carvedilol, microspheres, solvent evaporation, microparticle yield, in-vitro drug release.Abstract
The current study documents the formulation of Carvedilol-loaded microspheres, an antihypertensive drug, employing different cellulose derivative polymers. These microspheres were synthesized via the solvent evaporation method, employing cellulose derivative polymers. Carvedilol, a non-selective beta-blocker, is widely used in the treatment of hypertension and congestive heart failure. In the present study we have optimize the processing parameter and the various type of parameters were evaluated like microparticle yield, surface morphology, particle size analysis along with in-vitro drug release for prepared carvedilol microparticle. We have formulated six formulation of carvedilol microparticle out of which F2 showed the best result with production yield 75.31 % & drug encapsulation efficiency is 94.40 %.