Review Article on Controlled Release Matrix Pellets

Abstract

Controlled-release matrix pellets have emerged as an effective drug delivery system that enables sustained and predictable release of active pharmaceutical ingredients (APIs) over extended periods. These pellets are formulated by embedding the API within a polymeric matrix, which governs the release rate through diffusion, erosion, swelling, or other mechanisms. The main advantages of controlled-release matrix systems include reduced dosing frequency, improved patient compliance, and minimized side effects by maintaining steady plasma drug levels. This article provides an in-depth overview of the composition, preparation techniques, release mechanisms, challenges, and applications of controlled-release matrix pellets in pharmaceutical formulations.