Formulation, Development and Evaluation of Sustain Release Tablet of Venlafaxine

Authors

  • Shilki Kumari Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Raj.
  • Mayank Bansal Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Raj.
  • Hemant Menaria QC Head, Rusan Pharma Ltd., Mumbai, Maharashtra.
  • Rakesh Kumar Gupta Department of Pharmaceutical Analysis, Jaipur College of Pharmacy, Jaipur, Raj.
  • Sunil Sain Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Raj.

Abstract

Most common route of drug administration is the oral route and it is most widely used because of their advantages over others. Sustained release tablets are taken mostly once or twice a day and it provide action over an extended period of time and thus maintain the drug plasma level. Venlafaxine is an antidepressant drug belongs to BCS class I. Its half-life is 5 hours and maximum dose 225mg per day. For the manufacturing of these tablets Venlafaxine, HPMC K100M, Ethyl cellulose, Povidone K30, Cross linked PVP 0.45%, microcrystalline cellulose pH101, Talc, Colloidal Silicon Dioxide, Ethanol 95%, Hydrochloric acid were utilized. Number of pre-compression parameters were evaluated like thickness, hardness, friability, weight variation, in-vitro drug release studies, release along with accelerated stability studies. Outcomes of all the evaluation parameters were satisfying.

Keywords: Sustained release tablets, antidepressant drug, pre-compression parameters, accelerated stability studies.

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Published

2023-06-19

How to Cite

Shilki Kumari, Mayank Bansal, Hemant Menaria, Rakesh Kumar Gupta, & Sunil Sain. (2023). Formulation, Development and Evaluation of Sustain Release Tablet of Venlafaxine. International Journal of Health Advancement and Clinical Research (tz), 1(2). Retrieved from https://ijhacr.com/index.php/ijhacr/article/view/6

Issue

Vol. 1 No. 2 (2023): April-June

Section

Articles