A Comprehensive Review on Terbutaline Sulphate Tablet in Sublingual Route for The Treatment of Asthma

Abstract

Abstract:

The demand for fast disintegrating tablets has been growing during the last decade, due to the characteristics of fast disintegrating sublingual tablets for the potential emergency treatment. The sublingual course is a quick onset of activity and preferred patient consistency over orally ingested tablets. Sublingual from the Latin for "under the tongue", alludes to the pharmacological course of the organization by which drugs diffuse into the blood through tissues under the tongue. Sublingual drug delivery can be an alternative and better route when compared to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. Rapid onset of pharmacological effect is often desired for some drugs, especially those used in the treatment of acute disorders. Sublingual tablets disintegrate rapidly and the small amount of saliva present is usually sufficient for achieving disintegration of the dosage form coupled with better dissolution and increased bioavailability. Terbutaline is a β2-adrenergic agonist used to treat asthma and COPD. It works by relaxing bronchial smooth muscles, improving airflow.

Keywords: Sublingual Tablets, Better Bioavailability, Fast Disintegration, Tongue, Mucus, terbutaline sulphate.