An Overview on Topical Gel Drug Delivery Systems

Abstract

Topical gels are widely used pharmaceutical formulations designed for localized drug delivery through the skin or mucosal surfaces. These semi-solid preparations have gained popularity due to their ease of application, non-invasive nature, and ability to provide controlled drug release. This review explores the various aspects of topical gels, including their types, mechanisms of drug release. Additionally, it discusses various evaluation parameters of gels, their applications in dermatology and transdermal drug delivery, and recent advancements in gel-based drug delivery systems. Special emphasis is placed on novel gel types, such as thermoreversible, bioadhesive, and nano-based gels, which have expanded the scope of topical therapies. By analyzing current trends and challenges, this review provides insights into the future potential of topical gel formulations in pharmaceutical sciences.