Nanosuspensions: A Paradigm Shift in Drug Delivery Systems

Abstract

Nanosuspensions have emerged as a revolutionary drug delivery system, particularly effective in addressing the challenges associated with poorly water-soluble drugs. These colloidal dispersions, composed of nanosized drug particles stabilized by surfactants or polymers, significantly enhance solubility, dissolution rates, and bioavailability. They are versatile in their application, with suitability for oral, parenteral, ocular, pulmonary, and dermal routes of administration. This review discusses the types of nanosuspensions, methods for their evaluation, challenges faced during development and scale-up, and potential future advancements in the field. With the continuous evolution of nanotechnology, nanosuspensions offer a promising avenue for improving therapeutic outcomes and expanding the scope of pharmaceutical innovation.