Sustained Release Matrix Tablets: A Comprehensive Review

Abstract

Abstract:

Sustained release matrix tablets have emerged as a reliable drug delivery system designed to achieve controlled and prolonged therapeutic effects. By regulating drug release over an extended period, these formulations improve patient compliance, reduce dosing frequency, and maintain stable plasma drug concentrations. The matrix system, often composed of hydrophilic, hydrophobic, or inert materials, serves as the backbone for modulating release rates. This review explores the need for sustained release systems, various preparation methods, different polymers that can be used like hydrophilic polymers, hydrophobic polymers, inert polymers and natural polymers and materials used in formulating sustained release matrix tablets. It also discusses challenges, future prospects, and the potential role of advanced technologies in improving drug delivery efficiency.