Development And Evaluation of Natural Polymer-Based Sustained-Release Matrix Tablets of Aceclofenac

Abstract

The development of sustained-release drug delivery systems is a promising approach to improve patient compliance and therapeutic efficacy by maintaining consistent drug levels over extended periods. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), is widely used for pain management and inflammatory conditions but suffers from frequent dosing and potential gastrointestinal side effects. This study aims to formulate and evaluate sustained-release matrix tablets of Aceclofenac using natural polymers as matrix-forming agents. Natural polymers like Psidium guajava mucilage was investigated for their potential to modulate drug release and provide eco-friendly pharmaceutical alternatives. The prepared formulations were subjected to many evaluation parameters like appearance, dimension, weight variation, hardness, friability, drug content as well as in-vitro dissolution studies. A sustained delivery of medicament over a period of 12 hours is the result of an increase in the concentration of Psidium guajava mucilage. The investigation demonstrated that the release rate of formulation F9 from the matrix tablets is contingent upon the concentration of Psidium guajava, as drug release was observed to be delayed as the Psidium guajava mucilage content increased.