Formulation and Optimization of Ion Exchange Resin Beads of Tolperisone Hydrochloride Using 23 Factorial Desing
Keywords:
IERs, Tolperisone hydrochloride, bioavailability, encapsulation, hydrophobic polymer, micromeritics properties, SEM, 23 factorial design.Abstract
Ion exchange resins (IERs) are polymers that can exchange specific ions within a solution with ions that are attached to the resin itself. These resins are widely used in water purification, chemical processing, and various industrial applications for the removal of undesirable ions or the separation of valuable ones. This study aims to develop resin beads containing Tolperisone hydrochloride for controlled release using various cation exchange resins. Due to its brief half-life (1.5 - 2.5 hours) and limited bioavailability, encapsulation with a hydrophobic polymer via solvent evaporation microencapsulation will be used to extend drug release. The goal is to enhance the drug's therapeutic effect in treating muscle spasms by sustaining its release over a longer period. Optimization was done by using 23 factorial design and further evaluated for extent of coating, drug content, particle size, micromeritics properties, SEM, in-vitro dissolution investigation.
