Evaluation of Antifungal Properties of Fluconazole-Loaded Ethosomal Gel

Abstract

Ethosomal gels are advanced drug delivery systems that enhance the penetration of active pharmaceutical ingredients through the skin and mucosal layers. Fluconazole, a broad-spectrum antifungal agent, is commonly used to treat fungal infections. The present study aims to formulate an ethosomal gel containing Fluconazole and evaluate its antimicrobial activity against various fungal and bacterial strains. The study involves the preparation of ethosomes using various ingredients followed by incorporation into a gel base. The antimicrobial activity is determined using in-vitro techniques such as the agar well diffusion method. The results indicate enhanced antifungal activity of the ethosomal formulation compared to conventional Fluconazole gels, demonstrating its potential as an improved topical therapy.

Fluconazole, Ethosomal Gel, Antimicrobial Activity, Fungal Infections, Drug Delivery System.