How to design a structure-based In-silico approach for the therapeutic drug development for diabetes mellitus or obesity: A Systemic Review

Abstract

Obesity is a major contributing factor to other chronic non-communicable diseases and is strongly associated with Diabetes Mellitus. Computer modelling tools facilitate the comprehension of the interaction mechanisms between specific targets and substances of interest, hence enhancing the optimization of medication development. This article outlines two systematic review processes that aim to find therapeutic targets and models for the treatment of obesity or diabetes mellitus through in silico investigations. The protocol adheres to the requirements outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) and has been published in the International Prospective Register of Systematic Reviews database.